I don't think you'll find any OS/400 features that make it substantially easier. To do that, you'd probably need to buy a third-party data movement or replication product.
One approach would be using the CPYFRMIMPF CL command.
1. Define target table with DDS or SQL.
2. Export Excel file into delimited format.
3. FTP delimited format file to your iSeries server.
4. Use CPYFRMIMPF CL command to load the delimited format file into the target table.
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This was first published in June 2003