I'm not aware of such a problem, you should check and make sure that the client access is in it's latest version and patch level.
I will also consider the use lpr/lpd solution instead of pc5250 print emulation. If your sessions are meant for printers only, the following is a better approach:
1. Install the NT lpd service and start it.
2. On the AS/400 create a remote output queue/ the outq will point to queue on the NT machine.
This will send via lpr/lpd every spool in the specified queue to windows, and from there it is just a plain simple NT print request.
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